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Embed code for: Growth factors(#6)
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Extracellular stimuli that can increase cancerous growth
Possible therapeutic targets
What is the function of growth factors?
Movie 1: Growth factors
Movie 2: EGFR
Evidence of growth factor involvement in proliferation
Monolayer of fibroblasts wounded by the tip of a pipet:
How do they work?
Structure of GF receptors
Diversity of GF receptors
Table 5.1 The Biology of Cancer (© Garland Science 2007)
Growth factors and uncontrolled signaling
Homologies of GFR with viral oncogenes
Altered GF signalling: Ligand-independant
Table 5.2 The Biology of Cancer (© Garland Science 2007)
Ligand-dependant altered signalling
Figure 5.12b The Biology of Cancer (© Garland Science 2007)
Table 5.3 The Biology of Cancer (© Garland Science 2007)
Example of Ligand-dependant carcinogenesis
Breast carcinoma expressing:
Red: EGF receptor
Green: TGF-alpha (binds with EGF-R)
Merged image shown in bottom panel
Figure 5.12c The Biology of Cancer (© Garland Science 2007)
On the following picture representing normal epithelial cells or cancerous epithelial cells, draw the following growth factors and their receptors: EGF, TGF-a, PDGF