Access to the article is free, however registration and sign-in are required. Identification of targeting sequences needed for secretion of the virulence proteins encoded by mycobacteria has potential applications for the design of live, attenuated vaccines. Recently, a new protein secretion pathway, ESX-1 (ESAT-6 system-1) or Snm (secretion in mycobacteria), was discovered in M. tuberculosis , and is present in many other Gram-positive bacteria . This discovery has challenged our knowledge of t
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