Genetic and biochemical experiments over the past decade have allowed the construction of a viable working model for the molecular mechanisms underlying circadian rhythm generation in Drosophila. The basic mechanism consists of two intertwined transcription-translation negative feedback loops. One loop--the "positive loop"--controls the rhythmic expression of a Per-Arnt-Sim (PAS)-domain-containing positive transcription factor, Clock. The second loop--the "negative loop"--controls the transcript
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