Access to the article is free, however registration and sign-in are required. The predictability of cellular responses is the basis for applications as diverse as preventive medicine and the reengineering of microbes for biotechnology. An individual biological system functions optimally within an environmental space (defined by the ranges in any given parameter) in which it has evolved. Furthermore, within this defined space, changes in individual factors (temperature, pH, O2, etc.) do not occur
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