Access to the article is free, however registration and sign-in are required. One of the first to be discovered and still one of the most important, cyclic AMP is a second messenger inside cells, carrying information from outside signals to change processes inside. As described by Bourne in his Perspective and reported by Tesmer et al. and Sunahara et al., adenylyl cyclase, the enzyme that catalyzes this process, has now been crystallized with the molecule that turns it on, the G protein Ga, yie
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