Access to the article is free, however registration and sign-in are required. After proteins are made, they must be folded into their final structure. In a report in this week's issue of Science, Frydman and Hartl, on page 1497, compare how molecular chaperones (proteins that assist folding) affect folding of proteins as they are synthesized from ribosomes and proteins that have been artificially denatured. In his Perspective, Ellis discusses why the differences that are found tell us something
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