Access to the article is free, however registration and sign-in are required. Proteins and nucleic acids are transported into and out of the cell nucleus through nuclear pores. In his Perspective, Goldfarb discusses two reports in this issue in which a central control switch in nuclear transport is identified as Ran, a small guanosine triphosphatase. Not only is this molecule a key component in turning the import and export processes on and off (Richards et al.), but it is also a target for vesi
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