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Amino acid classifications, peptide bond formation, and protein folding interactions.
CHEM 108 SI
Session XVI – 3/16/17
SI Leader: Cassidy Sloot
Monday, Mar. 27th
Thursday, Mar. 23rd
6-8pm @ Ag Hall 100A
Amino acid review + chirality
Amino acid interactions
Amino Acids – Review
Classify the type (polar, nonpolar, acidic, basic).
Is it hydrophobic or hydrophilic?
Draw it at a high pH, low pH, and at it’s isoelectric pH.
What makes a molecule chiral?
4 different groups attached to one carbon
Amino Acids – Pulling it Together
Is it chiral or achiral?
Indicate the chiral center, if applicable.
Dipeptide: two AA’s, one peptide (amide) bond
Polypeptide: five AA’s, four peptide (amide) bonds
Where are the amino (N) and carboxyl (C) terminals?
Draw your amino acid after forming a peptide bond with glycine. Identify the amino and carboxyl terminals.
Summarize the differences between primary, secondary, tertiary, and quaternary protein structure.
List as many details as possible.
How are they all related?
Classify your amino acid (polar, non-polar, acidic, basic).
Based on the classification, what type of interactions would your amino acid participate in during protein folding (tertiary structure)?
Indicate where you would see hydrogen bonding between the backbones of your amino acid and glycine.
Lys - Ala - His - Gly - Lys - Lys - Val - Leu - Gly - Ala – (primary structure)
4 chains of hemoglobin assembled in
a protein (quaternary structure)
Amino Acid Parts Involved
Amino Acids Involved
covalent (peptide) bonds
amino & carboxyl
2. salt bridges
3. hydrogen bonding
4. disulfide bridges
2. basic & acidic
What is the main difference between fibrous and globular proteins?
Solubility & function
Fibrous insoluble; structure
Globular soluble; function (metabolism, transport, etc.)
Which levels of structure do denaturation and hydrolysis affect?
Denaturation secondary, tertiary, quaternary
T/F: all proteins have a quaternary structure.
I have no idea!
Which interaction(s) will glutamic acid participate in?
A & C
Identify the amino acids occupying the N- & C-terminals for this protein.
Lys - Ala - His - Gly - Lys - Lys - Val - Leu - Gly - Ala
N= Ala C= Lys
N= Ala C= Ala
N= Lys C= Ala
None of the above
I have no idea!