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Embed code for: Physiology SI 10.5.15
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Physiology SI 10/5/15
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Increase metabolic rate & heat; blood glucose & fat
Hypothroidism & cretinism; Graves Disease
Increased blood Ca2+ levels
Osteoclasts / bone matrix
Reduces blood Ca2+ levels
Used to treat osteoporosis
Hyposecretion of T3, T4
What is the function of T3, T4?
Increase metabolic rate and heat, Increase blood glucose and fat crucial for growth!
What happens if you don’t have enough T3, T4?
Stunted growth (mentally and physically), sterile
Take a minute to go through T3, T4 synthesis
T3, T4 Synthesis
TSH from anterior pituitary stimulates follicular cells to produce thyroglobulin
Thyroglobulin is produced via ER/Golgi and exocytosed into colloid
Iodide is absorbed from blood via secondary active transport
Iodide travels across cell and enters colloid via facilitated diffusion
Iodide is oxidized to iodine and attached to tyrosine A.A.s on thyroglobulin
The iodinated tyrosines are linked together to form T3, T4
This T3,T4-thyroglobulin complex is endocytosed by follicular cells
This endosome is joined with a lysosome
Enzymes in lysosome cleave T3,T4 from thyroglobulin
T3,T4 enter bloodstream
Thyroglobulin is recycled
Don’t forget the thymus!
Location of T cell maturation
Produces hormones thymulin, thymopoietins, thymosins
Act in the thymus itself for its functions
G – Zona glomerulosa
D – acronym goes down from outside to inside of cortex
F – Zona fasciculata
R – Zona reticularis
Water retention; Na+ reabsorption; K+ excretion
Suppress immune system; breakdown macros; increae blood glucose
Cushing’s disease; Addison’s disease
Hypersecretion – What happens when functions increase?
Suppress the immune system – risk infection/sickness
Increase blood glucose – hyperglycemia
Breakdown of macros – muscle and fat breakdown – thin arms
Yet stores fat in body and face
Hyposecretion – What happens when functions decrease/disappear?
Males – similar to testosterone; Females – Estrogen synthesis – sex chars; sex drive; puberty
Increased vasoconstriction; HR; blood glucose; bronchial dilation
Produce estrogen and progesterone
Secondary sex characteristics
A genetic mutation prevents the body from making TBGs. What might this lead to?
While repairing a tragic neck injury, the surgeon accidentally removes the entire thyroid (idiot). What hormones will be affected?
All of the above